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DoomsdaysCW<a href="https://beige.party/@kimlockhartga" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@kimlockhartga</a> <a href="https://kolektiva.social/tags/Henipavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Henipavirus</a> in Northern Short-Tailed <a href="https://kolektiva.social/tags/Shrew" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Shrew</a>, Alabama, USA Volume 31, Number 2—February 2025<a href="https://wwwnc.cdc.gov/eid/article/31/2/24-1155_article" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://wwwnc.cdc.gov/eid/article/31/2/24-1155_article</a>

Scientific FrontlineThe discovery of a <a href="https://mastodon.social/tags/henipavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#henipavirus</a> in North America is highly significant, as it suggests these <a href="https://mastodon.social/tags/viruses" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#viruses</a> may be more globally distributed than previously thought. <a href="https://mastodon.social/tags/Virology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Virology</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2025/01/vi01282501.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sflorg.com/2025/01/vi01282501.html</a>

ETIDIoHStructural #basis of #Nipah virus #replicationSource: BioRxIV, <a href="https://www.biorxiv.org/content/10.1101/2024.10.04.616610v1?rss=1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2024.10.04.616610v1?rss=1</a> Abstract Nipah virus (NiV) is a non-segmented negative-strand RNA virus (nsNSV) with high pandemic potential, as it frequently causes zoonotic outbreaks and can be transmitted from human to human. Its RNA-dependent RNA polymerase (RdRp) complex carries out viral genome replication and transcription and is therefore an attractive drug target. However, to date no structural data is available on the NiV RdRp complex. Here, we report cryo-EM structures of NiV RdRp in the apo and in an early elongation state with RNA and incoming substrate bound. The structure of the apo enzyme reveals the architecture of the NiV RdRp complex, which shows a high degree of similarity to other nsNSV RdRps. The structure of the RNA-bound NiV RdRp shows how the enzyme interacts with template and product RNA during early replication and how nucleoside triphosphates are bound in the active site. Comparisons show that RNA binding leads to rearrangements of key elements in the RdRp core and to ordering of the flexible C-terminal domains of NiV L required for RNA capping. Taken together, these results reveal the first structural snapshots of an actively replicating nsNSV RdRp and provide insights into the mechanisms of genome replication and transcription by NiV and related viruses.____<a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/abstract/" target="_blank">#abstract</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/biology-2/" target="_blank">#biology</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/dna/" target="_blank">#dna</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/genetics-2/" target="_blank">#genetics</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/henipavirus/" target="_blank">#henipavirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/nipah-virus-2/" target="_blank">#nipahVirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/research-2/" target="_blank">#research</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/rna/" target="_blank">#rna</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/science/" target="_blank">#science</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/India" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#India</a>'s <a href="https://mstdn.science/tags/Nipah" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Nipah</a> virus <a href="https://mstdn.science/tags/outbreak" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#outbreak</a>: What do we know so far? CNA: <a href="https://www.channelnewsasia.com/asia/india-nipah-virus-symptoms-what-we-know-about-outbreak-3773366" rel="nofollow noopener noreferrer" target="_blank">https://www.channelnewsasia.com/asia/india-nipah-virus-symptoms-what-we-know-about-outbreak-3773366</a> <a href="https://mstdn.science/tags/news" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#news</a> <a href="https://mstdn.science/tags/EIDs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EIDs</a> <a href="https://mstdn.science/tags/henipavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#henipavirus</a> <a href="https://mstdn.science/tags/encephalitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#encephalitis</a>

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