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#behaviour

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📰 "Goal learning, memory, and drift in the Drosophila head direction system"
biorxiv.org/content/10.1101/20
#Drosophila #Behaviour

bioRxiv · Goal learning, memory, and drift in the Drosophila head direction systemSelecting and memorizing goal direction are essential for navigation behavior. Heading information is represented in the head direction systems across species, including Drosophila. However, how navigation decisions are made and how goal memories are represented in these systems is little understood. Here, using a navigation learning assay for flies walking in virtual reality during two-photon imaging, we describe neural dynamics for direction selection and memory. We find that neurons which encode walking direction in the fan-shaped body, a navigation and learning related area in the center of the fly brain, show continuing autonomous activity or directional drift when the animal is at rest. Drift during rest centers around opposite directions to activity during walking, suggesting different computations between these two behavioral states. Targeted optogenetic activation of these neurons during rest is sufficient to induce a subsequent directional navigation preference. Learning leads to changes in drift distributions during rest depending on goal direction, revealing a memory in the network. The fly head direction system thus offers a compact architecture for direction selection, learning, and memory. Changes in neural representations due to goal learning and between rest and walking suggest similarities in navigation circuits across species. ### Competing Interest Statement The authors have declared no competing interest.

Maxwell Martin said she expected #Labour government “to understand that #fining vulnerable parents is #cruel, #idiotic, & they don’t.

The actor said compassion was leaching out of #schools

There’s no point in banging on about #behaviour & behaviour tsars. You can’t #teach #children to behave better by making them feel shit. It doesn’t work

We need to meet their needs. We need to make them feel they have worth.”

theguardian.com/education/2025

The Guardian · Anna Maxwell Martin calls for end to ‘cruel, idiotic’ fines for school absenceBy Sally Weale
bioRxiv · An optimized appetitive visual short-term memory paradigm in DrosophilaThe ability to generate and recall memory is a behavior that is evolutionarily conserved across the animal kingdom from humans to jellyfish. Memory not only allows previous experiences to inform future decision making, but it also amasses information essential to life, such as memory of quality food sources, shelter, and predator-related associations. Associative memory forms a relationship between two or more distinct and initially unrelated stimuli and can be defined by its temporal characteristics, such as shortand long-term duration, as well as the memory being appetitive or aversive, generating approach or avoidance behavior, respectively. Since its introduction as a memory model in the 1970s, the fruit fly, Drosophila melanogaster, has emerged as a powerful tool for the investigation of memory-related processes. While a variety of memory paradigms have been used extensively in Drosophila, such as appetitive and aversive olfactory memory, the use of appetitive visual memory remains infrequent. A previous study introduced a visual shortterm memory (STM) paradigm that could be used for the study of both appetitive and aversive visual memory in Drosophila. However, this protocol required 50+ flies per condition, with three conditions per experiment, and 15 or more replications were frequently used to assess memory. As a result, this paradigm requires substantial numbers of flies, time, and is impractical for large genetic screens. Here, building upon this previous work, we describe an optimized appetite visual STM paradigm in freely moving Drosophila. Using recently published data on sexual dimorphism, innate color preferences, and borrowing practices from related appetitive assays, we have established an approach that minimizes confounding factors, such as sexually dimorphic starvation survival and sucrose preference, as well as pre-training color preference variation between groups. In doing so, we present an appetitive visual STM paradigm requiring substantially fewer replicates and numbers of flies to produce significant learning. ### Competing Interest Statement The authors have declared no competing interest.

🚀 Some exciting news! Our team is taking part in Google Summer of Code, which is a remote, asynchronous, global opportunity.

This is a fantastic chance for someone to get paid to contribute to "movement" or our other open-source projects in neuroscience and animal behaviour.

If you know someone who might be interested, please share widely! 🌍

Full details are here:
neuroinformatics.dev/get-invol

neuroinformatics.devGoogle Summer of Code — NIU

#DietrichBonhoeffer's thought-provoking #TheoryofStupidity, a fascinating concept that delves into human #behaviour, #intelligence, and the nature of #societal #dynamics. There is a cycle at play, and you can break it, so watch to the end.

"Stupidity is a more dangerous enemy of goodness than evil..."

A timely video!

youtu.be/h9h0Yy2QdmM?si=5MZKwH

youtu.be- YouTubeEnjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.